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KMID : 1134820140430101477
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Journal of the Korean Society of Food Science and Nutrition
2014 Volume.43 No. 10 p.1477 ~ p.1483
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Anti-obesity Effects of African Mango (Irvingia gabonesis, IGOB 131TM) Extract in Leptin-deficient Obese Mice
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Lee Min-Hee
Nam Da-Eun
Kim Ok-Kyung
Shim Tae-Jin
Kim Ji-Hoon
Lee Jeong-Min
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Abstract
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This study investigated the anti-obesity effects of African mango (Irvingia gabonesis, IGOB 131TM) extract in leptin-deficient obese mice. Experimental groups were treated with two different doses of IGOB 131TM (1% and 2% in each AIN93G supplement) for 8 weeks. Treatment of obese mice with both low and high dose of IGOB 131TM significantly reduced body weight gain by 10.9% and 13.3%, respectively, compared to control obese mice. Subcutaneous adipose tissue weight of mice was significantly reduced by 18% by low-dose and 23% by high-dose supplementation. This result was supported by micro-CT analysis around the abdominal regions of mice, indicating that the adipose tissue area and volume were significantly reduced by treatment with IGOB 131TM. Serum levels of triglycerides in the low- and high-dose groups were reduced by 36.5% and 43.8%, respectively, upon treatment with IGOB 131TM, whereas total cholesterol levels were reduced by 31.8% and 35.4%. Interestingly, the serum LDL level decreased upon treatment with IGOB 131TM while the serum level of HDL dramatically increased upon high-dose treatment with IGOB 131TM, resulting in a significant reduction in the LDL to HDL ratio of 59.2%. These results were supported by the expression levels of enzymes and proteins related to lipid metabolism assessed by real-time PCR. There was a significant increase of in adiponectin expression as well as significant decreases in the expression of FAS, LPL, and lipid regulatory transcription factors such as PPAR-γ, C/EBP, and SREBP upon both low- and high-dose IGOB 131TM treatment. However, there was no statistical difference between low- and high-dose treatments. These results suggest that IGOB 131TM is able to regulate the serum lipid profiles by reducing triglyceride and increasing HDL levels as well as regulate expression of lipid metabolic factors, resulting in reduction of a weight gain in leptin-deficient obese mice.
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KEYWORD
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African mango, Irvingia gabonesis, anti-obesity, ob/ob mice
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